氯唑西林钠 (642-78-4)

常用名

氯唑西林钠

英文名

cloxacillin sodium
中文别名

氯洒西林;
6R)-3,3-二甲基-6-[5-甲基-3-(2-氯苯基)-4-异恶唑甲酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐;
英文别名

Tegopen;
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)-, hydrate (1:1:1);
Staphybiotic;
Sodium cloxacillin;
cloxacillin sodium hydrate;
Ankerbin;
Cloxapen;
Austrastaph;
(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt Monohydrate;
Prevencilina P;
Cloxacillin sodium salt hydrate;
Sodium cloxacillin monohydrate;
cloxacillin sodium monohydrate;
Orbenin;
Sodium (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate (1:1:1);
MFCD00150735;
Prostaphilin A;
Ekvacillin;
[(2S,5R,6R)-6-({[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]sodium hydrate (1:1);
sodium, [(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]-, hydrate (1:1);
Cloxacillin Sodium Salt;
EINECS 211-390-9;
Gelstaph;
Monosodium (2S,5R,6R)-6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Monohydrate;
Cloxacillin Sodium;
CAS号

642-78-4

分子量

475.878
密度

N/A

沸点

N/A
分子式

C₁₉H₁₇ClN₃NaO₅S

熔点

170ºC

更新时间：1970-01-01 00:00

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现货直购

产品相关信息

快速询盘

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品牌/公司

包装规格

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价格

数量

操作

吉至生化

1g

95%

现货

¥159

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源叶生物

1g

95%

现货

¥160

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吉至生化

5g

95%

现货

¥299

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源叶生物

5g

95%

现货

¥300

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源叶生物

50mg

95%

现货

¥570

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吉至生化

25g

95%

现货

¥999

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源叶生物

25g

95%

现货

¥1000

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氯唑西林钠百科资料

氯唑西林钠名称

中文名

氯唑西林钠
英文名

cloxacillin sodium
中文别名

氯洒西林 |6R)-3,3-二甲基-6-[5-甲基-3-(2-氯苯基)-4-异恶唑甲酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐 |
英文别名

Tegopen |4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)-, hydrate (1:1:1) |Staphybiotic |Sodium cloxacillin |cloxacillin sodium hydrate |Ankerbin |Cloxapen |Austrastaph |(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt Monohydrate |Prevencilina P |Cloxacillin sodium salt hydrate |Sodium cloxacillin monohydrate |cloxacillin sodium monohydrate |Orbenin |Sodium (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate (1:1:1) |MFCD00150735 |Prostaphilin A |Ekvacillin |[(2S,5R,6R)-6-({[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]sodium hydrate (1:1) |sodium, [(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-κO]-, hydrate (1:1) |Cloxacillin Sodium Salt |EINECS 211-390-9 |Gelstaph |Monosodium (2S,5R,6R)-6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Monohydrate |Cloxacillin Sodium |

氯唑西林钠生物活性

描述

Cloxacillin sodium 具有有效的抗菌活性，对Staphylococcus aureus 25923 的最小抑菌浓度为256 mg/L。
相关类别

研究领域 >> 感染研究领域 >> 炎症/免疫信号通路 >> 抗感染 >> 细菌
体外研究

氯唑西林是一种抗生素，用于研究许多细菌感染[1]。细胞活力测定[1]细胞系：株M12和M60。浓度：0.5μg/mL，培养时间：4-24h。结果：细菌数量明显减少。
体内研究

氯唑西林钠（50mg/kg，皮下注射）对金黄色葡萄球菌有显著的抗菌作用[3]动物模型：小鼠[2]。剂量：10mg/kg（药理分析）。给药：皮下注射。结果：10min时血浆浓度达到最大值8.4μg/mL，半衰期约15min。动物模型：用0.1ml生理盐水注射约2×106cfu细菌的小鼠右大腿肌肉无菌注射[3]。剂量：0-500 mg/kg。给药：感染后1小时在颈部皮下注射。结果：18小时后测得的存活金黄色葡萄球菌数量显著减少。
参考文献

[1]. J C Anderson, et al. The Effect of Incorporation of Cloxacillin in Liposomes on Treatment of Experimental Staphylococcal Mastitis in Mice. J Vet Pharmacol Ther. 1986 Sep;9(3):303-9. [2]. W Calame, et al. Influence of Etoposide and Cyclophosphamide on the Efficacy of Cloxacillin and Erythromycin in an Experimental Staphylococcal Infection. Antimicrob Agents Chemother. 1989 Jun;33(6):980-2. [3]. Peter H Nibbering, et al. 99mTc-Labeled UBI 29-41 Peptide for Monitoring the Efficacy of Antibacterial Agents in Mice Infected With Staphylococcus Aureus. J Nucl Med. 2004 Feb;45(2):321-6.