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西洛多辛 (160970-54-7)
- 常用名西洛多辛英文名1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
- 中文别名
西罗多辛;
西洛多新;
西洛多辛杂质;
西洛多辛(R);
2,3-二氢-1-(3-羟丙基)-5-[(2R)-2-[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙胺基]丙基]-1H-吲哚-7-甲酰胺;
- 英文别名
1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-7-indolinecarboxamide;
KAD 3213;
1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide;
[3H]-Silodosin;
Rapaflo;
[14C]-Silodosin;
1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-;
UNII-CUZ39LUY82;
Silodyx;
Urief;
Silodosin;
KMD-3213;
- CAS号160970-54-7分子量495.534
- 密度1.2±0.1 g/cm3沸点601.4±55.0 °C at 760 mmHg
- 分子式C25H32F3N3O4熔点N/A
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更新时间:1970-01-01 00:00
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10mM (in 1mL DMSO)
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西洛多辛 百科资料
- 中文名西洛多辛
- 英文名1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
- 中文别名西罗多辛 |西洛多新 |西洛多辛杂质 |西洛多辛(R) |2,3-二氢-1-(3-羟丙基)-5-[(2R)-2-[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙胺基]丙基]-1H-吲哚-7-甲酰胺 |
- 英文别名1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-7-indolinecarboxamide |KAD 3213 |1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide |[3H]-Silodosin |Rapaflo |[14C]-Silodosin |1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]- |UNII-CUZ39LUY82 |Silodyx |Urief |Silodosin |KMD-3213 |
- 描述Silodosin (Rapaflo; KMD-3213)是α1-肾上腺素受体拮抗剂。
- 相关类别信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体 研究领域 >> 内分泌
- 参考文献[1]. Kobayashi, Shinya; Tomiyama, Yoshitaka; Effects of silodosin and tamsulosin on the urethra and cardiovascular system in young and old dogs with benign prostatic hyperplasia. European Journal of Pharmacology (2009), 613(1-3), 135-140. [2]. Tatemichi, Satoshi; Tomiyama, Yoshitaka; Maruyama, Itaru; Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia. Neurourology and Urodynamics (2006), 25(7), 792-794. [3]. Osman NI, Chapple CR, Cruz F, Desgrandchamps F, Llorente C, Montorsi F.Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.Expert Opin Pharmacother. 2012 Oc [4]. Cui Y, Zong H, Zhang Y.The efficacy and safety of silodosin in treating BPH: a systematic review and meta-analysis.Int Urol Nephrol. 2012 Aug 24. [5]. Goseki T, Ishikawa H, Ogasawara S, Mashimo K, Nemoto N, Taguchi Y, Yago K, Shimizu K.Effects of tamsulosin and silodosin on isolated albino and pigmented rabbit iris dilators: Possible mechanism of intraoperative floppy-iris syndrome.J Cataract Refract Su
- 密度1.2±0.1 g/cm3
- 沸点601.4±55.0 °C at 760 mmHg
- 分子式C25H32F3N3O4
- 分子量495.534
- 闪点317.5±31.5 °C
- 精确质量495.234497
- PSA97.05000
- LogP2.52
- 蒸汽压0.0±1.8 mmHg at 25°C
- 折射率1.552
西洛多辛 合成路线
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