土贝母苷甲 (102040-03-9)

常用名

土贝母苷甲

英文名

Tubeimoside A
中文别名

土贝母苷甲;
假贝母;
土贝母皂甙;
英文别名

TUBEIMOSIDE 1;
β-D-Xylopyranosyl-(1->3)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-{[(2R,3S,4S,4aR,5aS,8S,9S,9aR,17aR,17bR,19aR,19bS,21aS,25aS,27aR,27bR,29S,29aR,30aR)-3,4,8,9,13,29-hexahydroxy-2-(hydroxymethyl)-1 3,17a,19a,19b,24,24,27b-heptamethyl-11,15-dioxo-3,4,4a,7,8,9,9a,12,13,14,15,17a,18,19,19a,19b,20,21,22,23,24,25,25a,27,27a,27b,28,29,29a,30a-triacontahydro-2H,5aH,11H,17H-piceno[3,4-h]dipyrano[3,2-b:3 ;',2'-e][1,4,7,11]tetraoxacyclohexadecin-21a(;
TubeimosideI;
TUBELMOSIDEA;
TUBEMOSIDE A;
TUBEIMOSIDE I (RG);
(1S,4S,7S,8S,9R,11S,13S,14S,18S,22S,25S,27R,28S,29S,30R,32R,34R,35S,37R,38R,41R,42R,46S,53S,54R,55R,56R,57S,58R)-7,8,18,28,29,35,55,56,58-Nonahydroxy-30,54-bis(hydroxymethyl)-13,18,37,41,48,48,53,54-o ;ctamethyl-2,16,20-trioxo-3,5,10,12,15,21,24,26,31,33-decaoxadecacyclo[39.9.3.2.2.1.0.0.0.0.0]octapentacont-44-en-57-yl β-D-xylopyranoside;
Olean-12-en-28-oicacid,3-[[2-O-[4-O-(4-carboxy-3;
α-L-Arabinopyranose, O-β-D-xylopyranosyl-(1->3)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[[(2R,3S,4S,4aR,5aS,8S,9S,9aR,17aR,17bR,19aR,19bS,21aS,25aS,27aR,27bR,29S,29aR,30aR)-3,4,4a,5a,8,9,9a ,12,13,14,15,17a,18,19,19a,19b,20,21,22,23,24,25,25a,27,27a,27b,28,29,29a,30a-triacontahydro-3,4,8,9,13,29-hexahydroxy-2-(hydroxymethyl)-13,17a,19a,19b,24,24,27b-heptamethyl-11,15-dioxo-2H,7H,11H,17H- piceno[3,4-h]dipyrano[3,2-b:3',2'-e][1,4,7,1;
Lobatoside H;
Tubeimoside I;
CAS号

102040-03-9

分子量

1319.435
密度

1.5±0.1 g/cm3

沸点

N/A
分子式

C₆₃H₉₈O₂₉

熔点

N/A

更新时间：1970-01-01 00:00

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20mg

98%以上

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20mg

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诗丹德

20mg

HPLC≥98%

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源叶生物

20mg

95%(HPLC-ELSD)

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陌孚

20mg

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普西唐

20mg

≥98%(HPLC),分析标准品

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源叶生物

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95%(HPLC-ELSD)

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吉至生化

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土贝母苷甲百科资料

土贝母苷甲名称

中文名

土贝母皂甙甲
英文名

Tubeimoside A
中文别名

土贝母苷甲 |假贝母 |土贝母皂甙 |
英文别名

TUBEIMOSIDE 1 |β-D-Xylopyranosyl-(1->3)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-{[(2R,3S,4S,4aR,5aS,8S,9S,9aR,17aR,17bR,19aR,19bS,21aS,25aS,27aR,27bR,29S,29aR,30aR)-3,4,8,9,13,29-hexahydroxy-2-(hydroxymethyl)-1 3,17a,19a,19b,24,24,27b-heptamethyl-11,15-dioxo-3,4,4a,7,8,9,9a,12,13,14,15,17a,18,19,19a,19b,20,21,22,23,24,25,25a,27,27a,27b,28,29,29a,30a-triacontahydro-2H,5aH,11H,17H-piceno[3,4-h]dipyrano[3,2-b:3 ;',2'-e][1,4,7,11]tetraoxacyclohexadecin-21a( |TubeimosideI |TUBELMOSIDEA |TUBEMOSIDE A |TUBEIMOSIDE I (RG) |(1S,4S,7S,8S,9R,11S,13S,14S,18S,22S,25S,27R,28S,29S,30R,32R,34R,35S,37R,38R,41R,42R,46S,53S,54R,55R,56R,57S,58R)-7,8,18,28,29,35,55,56,58-Nonahydroxy-30,54-bis(hydroxymethyl)-13,18,37,41,48,48,53,54-o ;ctamethyl-2,16,20-trioxo-3,5,10,12,15,21,24,26,31,33-decaoxadecacyclo[39.9.3.2.2.1.0.0.0.0.0]octapentacont-44-en-57-yl β-D-xylopyranoside |Olean-12-en-28-oicacid,3-[[2-O-[4-O-(4-carboxy-3 |α-L-Arabinopyranose, O-β-D-xylopyranosyl-(1->3)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[[(2R,3S,4S,4aR,5aS,8S,9S,9aR,17aR,17bR,19aR,19bS,21aS,25aS,27aR,27bR,29S,29aR,30aR)-3,4,4a,5a,8,9,9a ,12,13,14,15,17a,18,19,19a,19b,20,21,22,23,24,25,25a,27,27a,27b,28,29,29a,30a-triacontahydro-3,4,8,9,13,29-hexahydroxy-2-(hydroxymethyl)-13,17a,19a,19b,24,24,27b-heptamethyl-11,15-dioxo-2H,7H,11H,17H- piceno[3,4-h]dipyrano[3,2-b:3',2'-e][1,4,7,1 |Lobatoside H |Tubeimoside I |

土贝母苷甲生物活性

描述

土贝母苷甲(Tubeimoside I)是中药土贝母提取物，已被证明为人类各种癌症的一种有效的抗肿瘤剂。
相关类别

信号通路 >> 其他 >> 其他研究领域 >> 癌症天然产物 >> 萜类化合物和糖苷
参考文献

[1]. Wang Y, et al. Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells. Biol Pharm Bull. 2011;34(6):831-8. [2]. Xu Y, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. [3]. Wu Q, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. [4]. Liu HZ, et al. Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways. Mol Med Rep. 2011 Sep-Oct;4(5):985-92. [5]. Chen WJ, et al. Tubeimoside-1 induces G2/M phase arrest and apoptosis in SKOV-3 cells through increase of intracellular Ca2+ and caspase-dependent signaling pathways. Int J Oncol. 2012 Feb;40(2):535-43.

土贝母苷甲物理化学性质

密度

1.5±0.1 g/cm3
分子式

C₆₃H₉₈O₂₉
分子量

1319.435
精确质量

1318.619385
PSA

445.19000
LogP

6.38
折射率

1.637

土贝母苷甲合成路线

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